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Fc-Dependent Mechanisms of Antibody-Mediated Killing (R01 Clinical Trial Not Allowed)
The purpose of this notice of funding opportunity (NOFO) is to support basic research that will elucidate mechanisms of Fc-mediated antibody functions, including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP).
Supported studies are expected to generate foundational data and tools that can be applied to the prediction of Fc-mediated killing activity by antibodies.
Such data should accelerate development of therapeutic monoclonal antibodies and design of vaccines or vaccine-adjuvant combinations that induce antibody responses capable of killing infected host cells, particularly in cases where induction of neutralizing antibodies fails or is insufficient for clearance of infection
Supported studies are expected to generate foundational data and tools that can be applied to the prediction of Fc-mediated killing activity by antibodies.
Such data should accelerate development of therapeutic monoclonal antibodies and design of vaccines or vaccine-adjuvant combinations that induce antibody responses capable of killing infected host cells, particularly in cases where induction of neutralizing antibodies fails or is insufficient for clearance of infection
Related Programs
Allergy, Immunology and Transplantation Research
Department of Health and Human Services
Agency: Department of Health and Human Services
Office: National Institutes of Health
Estimated Funding: $8,000,000
Office: National Institutes of Health
Estimated Funding: $8,000,000
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-23-054.html
Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession.
Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-23-054.html
Contact:
Agency Email Description:
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Agency Email:
Date Posted:
2023-09-26
Application Due Date:
Archive Date:
2024-03-02
