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Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology (R01 Clinical Trial Optional)
Reissue of PAR-21-263 to comply with DMS Policy.
This Notice of Funding Opportunity (NOFO) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria).
Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed.
This NOFO seeks research that addresses the following questions:
do the different domains of behavior segregate from each other? How much do they rely on distinct vs.
overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time.
This NOFO seeks to promote projects where the computational and the experimental components are well-integrated.
The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness.
This Notice of Funding Opportunity (NOFO) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria).
Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed.
This NOFO seeks research that addresses the following questions:
do the different domains of behavior segregate from each other? How much do they rely on distinct vs.
overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time.
This NOFO seeks to promote projects where the computational and the experimental components are well-integrated.
The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness.
Agency: Department of Health and Human Services
Office: National Institutes of Health
Estimated Funding: $55,000
Office: National Institutes of Health
Estimated Funding: $55,000
Who's Eligible
Obtain Full Opportunity Text:
https://grants.nih.gov/grants/guide/pa-files/PAR-23-307.html
Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession.
Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/pa-files/PAR-23-307.html
Contact:
Agency Email Description:
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Agency Email:
Date Posted:
2023-09-19
Application Due Date:
Archive Date:
2023-12-07
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