-Purpose.

Biomedical research laboratories increasingly undertake a software development project to solve a problem of interest specifically related to that laboratory.

These software packages sometimes become useful to a much broader community of users that can include translational and

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clinical researchers.

The goal of this program announcement is to support the continued development, maintenance, testing and evaluation of existing software.

The proposed work should apply best practices and proven methods for software design, construction, and implementation to extend the applicability of existing biomedical informatics/computational biology software to a broader biomedical research community.

-Mechanism of Support.

This FOA will utilize the NIH Research Project Grant (R01) award mechanism -Funds Available and Anticipated Number of Awards.

Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

The total amount awarded and the number of awards will depend upon number, quality, duration, and costs of the applications received.