Office of Science Grants

The U.S. Department of Energy Office of Science is the lead federal agency supporting fundamental scientific research for energy and the Nation’s largest supporter of basic research in the physical sciences.

The Office of Science portfolio has two principal thrusts: direct support of scientific research and direct support of the development, construction, and operation of unique, open-access scientific user facilities.



Department of Health and Human Services
 $62,853,680,968 Department of Transportation
 $56,443,571,981 Environmental Protection Agency
 $35,751,587,496 Department of Energy
 $24,661,368,000 National Aeronautics and Space Administration
 $14,032,768,821 Department of Homeland Security
 $13,986,266,741 Department of Labor
 $10,348,285,755 Department of Defense
 $10,111,366,675 Department of the Interior
 $9,806,569,960 Department of Agriculture
 $8,296,397,040 Agency for International Development
 $7,754,781,106 Department of Commerce
 $6,871,103,950 Department of Housing and Urban Development
 $6,642,477,476 Department of State
 $6,042,701,916 Department of Justice
 $5,571,395,802 Department of Education
 $2,642,831,221 Department of the Treasury
 $1,019,380,000 Other Agencies
 $724,036,487


The DOE SC program in Advanced Scientific Computing Research (ASCR) hereby announces its interest in basic research to explore potentially high-impact approaches in scientific computing and...more
Posted On - 2025-01-20


The DOE SC programs in Basic Energy Sciences (BES) and Advanced Scientific Computing Research (ASCR) announce their interest in receiving applications from interdisciplinary teams to establish...more
Posted On - 2025-01-17


Isotopes are high-priority commodities of strategic importance for the Nation and are essential in medical diagnosis and treatment, discovery science, national security, industrial processes,...more
Posted On - 2025-01-17




The Office of Science’s (SC) mission is to deliver scientific discoveries and major scientific tools to transform our understanding of nature and advance the energy, economic, and national...more
Posted On - 2025-01-17


The DOE SC program in Fusion Energy Sciences (FES) and the NNSA Defense Program (DP) Office of Experimental Sciences jointly announce their interests in receiving applications for new and renewal...more
Posted On - 2025-01-16


The DOE SC program in Fusion Energy Sciences (FES) hereby announces its interest in receiving new or renewal single-investigator or small-group applications to carry out hypothesis-driven...more
Posted On - 2025-01-14


The DOE SC program in Fusion Energy Sciences (FES) hereby announces its interest in applications for a Private Facility Research (PFR) program to support public research utilizing world leading...more
Posted On - 2025-01-08




This NOFO describes two distinct funding opportunities for DOE: the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR) programs for Fiscal Year (FY) 2025....more
Posted On - 2024-12-27


The DOE SC program in Biological and Environmental Research (BER) announces it is receiving applications for research within the Biological Systems Science Division’s (BSSD) Genomic Science...more
Posted On - 2024-12-11





Social Entrepreneurship
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