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A Consortium for Gut-Brain Communication in Parkinsons Disease (U24 Clinical Trial not allowed)
Parkinsons disease (PD) is the second most common and fastest growing neurodegenerative disorder, with approximately 60,000 Americans diagnosed annually.
PD symptoms are not limited to motor dysfunction and more than 50% of patients who develop PD often have a history of bowel complaints affecting nearly all parts of the gastrointestinal (GI) system.
These SI symptoms often precede the onset of motor symptoms, indicating that GI dysfunction may be an early manifestation of the disease and the gut may be an unexplored diagnostic and/or therapeutic target.
The purpose of this Funding Opportunity Announcement (FOA) is to establish a Gut Brain Parkinson's Diesase Consortium (GBPDC) The Data Coordinating Center (DCC) of the GBPDC will coordinate collaboration among the Gastroenterology Neurology Research Centers (GNRCs, as described in the companion FOA, RFA-DK-22-036), enrollment of subjects into the study, submission of data and other biological samples to central repositories, processing of biospeciments, submission of clinical, cellular and molecular data to central databases, and data analysis.
The DCC will manage the operations of the GBPDC Steering Committee and other operational committees and provide the infrastructure for the efficient design and conduct of multicenter clinical studies and establishe a repostiory of patient samples that may be used for ancillary studies of etiology and pathogenesis.
The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the GBPDC.
PD symptoms are not limited to motor dysfunction and more than 50% of patients who develop PD often have a history of bowel complaints affecting nearly all parts of the gastrointestinal (GI) system.
These SI symptoms often precede the onset of motor symptoms, indicating that GI dysfunction may be an early manifestation of the disease and the gut may be an unexplored diagnostic and/or therapeutic target.
The purpose of this Funding Opportunity Announcement (FOA) is to establish a Gut Brain Parkinson's Diesase Consortium (GBPDC) The Data Coordinating Center (DCC) of the GBPDC will coordinate collaboration among the Gastroenterology Neurology Research Centers (GNRCs, as described in the companion FOA, RFA-DK-22-036), enrollment of subjects into the study, submission of data and other biological samples to central repositories, processing of biospeciments, submission of clinical, cellular and molecular data to central databases, and data analysis.
The DCC will manage the operations of the GBPDC Steering Committee and other operational committees and provide the infrastructure for the efficient design and conduct of multicenter clinical studies and establishe a repostiory of patient samples that may be used for ancillary studies of etiology and pathogenesis.
The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the GBPDC.
Related Programs
Diabetes, Digestive, and Kidney Diseases Extramural Research
Department of Health and Human Services
Agency: Department of Health and Human Services
Office: National Institutes of Health
Estimated Funding: $300,000
Office: National Institutes of Health
Estimated Funding: $300,000
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-23-001.html
Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-23-001.html
Contact:
Agency Email Description:
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Agency Email:
Date Posted:
2023-07-31
Application Due Date:
Archive Date:
2023-12-21
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