The purpose of this Notice of Funding Opportunity (NOFO) is to reissue PAR-24-256 "Feasibility Trials of the NIH Music-based Interventions Toolkit for Brain Disorders of Aging (R34 Clinical Trial Required)" in order to support proof-of-concept feasibility trials guided by the NIH Music-based
Interventions (MBI) Toolkit for research on brain disorders of aging.
These early stage clinical trials will generate evidence supporting the validity of the NIH MBI Toolkits guiding principles as well as the necessary pilot data to assess the feasibility of the design for a subsequent clinical efficacy or effectiveness study (or pragmatic clinical trial) using music-based interventions in the context of brain disorders of aging, including but not limited to Alzheimers disease and Alzheimers disease-related dementias, Parkinsons disease, and stroke.
The data collected should address gaps in scientific knowledge in order to facilitate development of a competitive large-scale clinical trial.