The purpose of this NOFO is to solicit UG3/UH3 phased award research applications to conduct efficient, large-scale pragmatic clinical trial and/or implementation science Demonstration Projects within the infrastructure of the NIH-DoD-VA Pain Management Collaboratory (PMC) on non-opioid approaches to
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pain management and other comorbid conditions in U. S. veterans, military personnel, and their families.
Additional emphasis on a whole person approach to pain management will be added as a priority for NCCIH and partnering ICOs will also add their priority areas that include pain.
This NOFO will add a trial supported by the HEAL Initiative, an NIH-wide research effort aimed at addressing the opioid epidemic in part by identifying effective, non-opioid pain management solutions.
The PMC established a Coordinating Center in 2017 that provides national leadership and technical expertise for all aspects of PMC research including assistance to Demonstration Project grant awardees.