Broad-Spectrum Antagonists For Editors (B-SAFE)

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to identify and optimize novel molecules that exhibit inhibitory effects on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins (CRISPR-Cas) gene editing processes.

The

credit:


Broad-Spectrum Antagonists for Editors (B-SAFE) program is explicitly seeking transformative approaches enabling the discovery or design of novel inhibitors of gene editing technologies with enhanced activity, utility, and breadth of coverage.

Novel inhibitor activity will be assessed in vitro over the course of the program and a subset of top performing molecules will be selected for scale-up at quantities sufficient for testing and evaluation by Department of Defense (DoD) stakeholders.

In concert, DARPA is interested in exploring methods to rapidly discover inhibitor molecules for novel gene editing technologies beyond CRISPR-Cas systems to keep pace with the rapidly advancing field and promote the safe, controlled use of these technologies.

Research that generates incremental improvements to the existing state-of-the-art are specifically excluded.
Related Programs

Research and Technology Development

Department Of Defense


Agency: Department of Defense

Office: DARPA - Biological Technologies Office

Estimated Funding: $100,000


Relevant Nonprofit Program Categories





Obtain Full Opportunity Text:
SAM.gov Contract Opportunities

Additional Information of Eligibility:
All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA.

See the Eligibility Information section of the BAA for more information.

Full Opportunity Web Address:
https://sam.gov/opp/5f73920279b745a491b865013ad749c8/view

Contact:


Agency Email Description:
Agency POC

Agency Email:


Date Posted:
2024-06-14

Application Due Date:


Archive Date:
2024-09-11



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