The purpose of this Notice of Funding Opportunity (NOFO) is to support pilot research to develop and test behavioral implementation strategies for biomedical interventions (e.g., oral PrEP, condoms) to improve HIV and STI prevention implementation among disproportionately affected populations, especially

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Black/African American (Black) and Hispanic/Latino (Hispanic) gay, bisexual, and other men who have sex with men (MSM) without HIV who report substance use (drug or alcohol).

The study design and sample size should meet minimum requirements for consideration of the CDC Compendium of Best Evidence (https://www.cdc.gov/hivpartners/php/compendium/) and thus may have the potential for future CDC HIV prevention funding implementation in jurisdictions around the United States.

The applicants should have access to research participants in priority jurisdictions outlined in Ending the HIV Epidemic in the United States (EHE), in support of the goals of EHE (Ending the HIV Epidemic in the US (EHE) EHE Initiative CDC), the HIV National Strategic Plan for the United States:
A Roadmap to End the HIV Epidemic (2021-2025) (https://www.cdc.gov/nchhstp/media/pdfs/2024/08/hiv-national-strategic-plan-2021-202 5. pdf), and other federal prevention planning efforts.