-Purpose.

This FOA, entitled Research to Advance Vaccine Safety, is issued by the National Institutes of Health and encourages Research Project Grant (R01) applications from institutions/organizations that propose to support research that will contribute to the overall understanding of vaccine

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safety.�This R01 research opportunity invites studies that address scientific areas potentially relevant to vaccine safety such as 1) physiological and immunological responses to vaccines and vaccine components, 2) how genetic variations affect immune/physiological responses that may impact vaccine safety, 3) identification of risk factors and biological markers that may be used to assess whether there is a relationship between certain diseases or disorders and licensed vaccines, or 4) the application of genomic/molecular technologies to improve knowledge of vaccine safety.

-Mechanism of Support.

This FOA will use the NIH Research Project Grant (R01) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-08-257 that encourages applications under the NIH Exploratory/Developmental (R21) grant mechanism (add:
FOA numbers/URLs).-Funds Available and Anticipated Number of Awards.

Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

The total amount awarded and the number of awards will depend upon the, numbers, quality, duration, and costs of the applications received.