Purpose.

This Funding Opportunity Announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) encourages Small Research Project Grant (R03) applications from institutions/ organizations that propose research relevant to the basic understanding

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and development of therapeutic interventions for currently screened conditions and high priority genetic conditions for which screening could be possible in the near future.

In this FOA, a high priority condition is one for which the development of an efficacious therapy would make the condition amenable to newborn screening.The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources.

Mechanism of Support.

This FOA will utilize the NIH Small Research Grant (R03) award mechanism and runs in parallel with two FOAs of identical scientific scope, PAR-10-230 and PAR-10-232, that encourage applications under the R01, R21 mechanisms (FOA numbers/URLs).

Funds Available and Anticipated Number of Awards.

Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.