Purpose.

This FOA issued by the National Institute of Dental and Craniofacial Research solicits Research Project Grant (R01) applications from institutions/organizations that will elucidate the molecular mechanisms of resolution of acute and chronic inflammation, and will develop novel multidisciplinary

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approaches for predictable control and patterning of tissue inflammatory microenvironments.

Achieving the goals of this FOA will result in derivation of novel concepts and paradigms for promoting inflammation resolution, in overcoming tissue fibrosis and scarring, and in regenerating and reconstructing diseased and injured oral and craniofacial tissues.

Toward these goals, this FOA will require interdisciplinary and multidisciplinary research that integrates advances in disciplines such as cell and developmental biology, stem cell biology, and immunology, with advances in chemistry, pharmacology, and bioengineering.

Use of the multiple PI application format is strongly encouraged for this FOA.



Mechanism of Support.

This FOA will use the NIH Research Project Grant (R01) funding mechanism and runs in parallel with an FOA of identical scientific scope, RFA-DE-09-002, that solicits applications under the R21 funding mechanism.



Funds Available and Anticipated Number of Awards.

The NIDCR intends to commit up to a total of $ 3. 0 million in 2009 through this announcement and the companion FOA, RFA-DE-09-002 (R21), to support approximately 7-9 awards.

Awards issued under this FOA are contingent upon availability of funds and the submission of a sufficient number of meritorious applications.



Budget and Project Period.

The total project period for an application submitted in response to this funding opportunity may not exceed five years.