Purpose.

This AHRQ Funding Opportunity Announcement (FOA), supported by funds provided to AHRQ under the American Recovery and Reinvestment Act of 2009 (Recovery Act or ARRA), Public Law 111-5, invites Research Demonstration and Dissemination grant (R18) applicationsto promote the increased implementation

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and widespread use of findings from comparative effectiveness research (CER) that have been demonstrated to improve the prevention, diagnosis, management or treatment of a clinical condition or to otherwise improve care quality, improve access to care, reduce disparities, or improve population-based measures of health outcomes.

For purposes of this FOA, the scope of CER findings includes not only clinical findings but also findings on the effectiveness of implementation approaches, including behavioral change and delivery system strategies, as spelled out in the Federal Coordinating Council recommendations and Institute of Medicine (IOM) recommendations.

This FOA also reflects HHS recognition that, for the CER enterprise to be successful, funds must be directed at accelerating the dissemination and translation of CER findings into health care practice improvement.

To achieve maximum impact, applicants will leverage broad-based, multi-stakeholder or multi-site collaborations or partnerships to develop and implement comprehensive initiatives composed of one or more interventions and strategies, including, but not limited to, those listed below (see below, Nature of this Funding Opportunity.