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DoD Arthritis, Focused Research Award
The FY24 ATRP FRA is intended to support conceptually innovative, high-risk/potentially high-reward research that could ultimately lead to critical discoveries and/or improvements in patient care or quality of life for people impacted by arthritis.
Research addressing all types of arthritis is encouraged including but not limited to osteoarthritis, post-traumatic arthritis, inflammatory arthritis, juvenile arthritis, and rheumatoid arthritis.
The ATRP encourages applications that address sex as a biological variable and understudied arthritis types.
The ATRP also encourages applicants to consider whether large data sets or existing studies/consortia can be leveraged to maximize the potential impact of proposed studies.Applicants must address how the proposed research may eventually impact patient care and reduce the burden of disease.
It is expected that any research findings would benefit Service Members, their Families, Veterans, and the general public.
To meet the intent of the award mechanism, applications must specifically address at least one FY24 ATRP FRA focus area, listed in Section II.A.1, above.
Important aspects of this award mechanism include:Impact:
A key aspect of this award mechanism is impact.
The application should explicitly state how outcomes of the proposed research will have a significant impact on the advancement of arthritis research, potential for exploration of novel ideas, and/or patient care practices.
The application should clearly indicate how the research addresses the impact of arthritis in the military, which may include its effect on Service Member recruitment, retention, and recovery.
Applicants may also choose to include impacts to the Military Health System, which provides health care support to Service Members and their Families (Eligibility TRICARE).Research Levels:
The FY24 ATRP FRA offers funding for two Research Levels (refer to Section II.D.5 Funding Restrictions).
Only one Research Level category may be chosen per application.
It is the responsibility of the applicant to select the level that aligns with the scope of the proposed research.
The Research Level should be selected based on the research scope and not on the amount of the budget.
The following are generalized descriptions of the scope of the research appropriate for each level:• Research Level 1:
Supports exploratory, high-risk/high-reward research that is in the early stages of idea development.
Research must have the potential to yield new avenues of investigation, such as new approaches, new research tools, or new paradigms.
Early career investigators are particularly encouraged to apply to this research level.• Research Level 2:
Supports the advancement of preclinical research toward clinical translation.Preliminary data are required:
Applications must include preliminary and/or published data to support the proposed research project.
The included data may originate from other researchers or research conducted by the applicant(s).
Applicants must demonstrate logical reasoning for the proposed work.
To be competitive, the application must include a sound scientific rationale and a well-formulated, testable hypothesis established through a critical review and analysis of the literature.Advancing Women’s Health Research and Innovation:
The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable.
Such research should relate anticipated project findings to improvements in women’s health outcomes and/or advancing knowledge for women's health.
The ATRP therefore encourages research that addresses how arthritis and arthritis care may affect women uniquely, disproportionately, or differently from men.Rigor of Experimental Design:
All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research.
The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature1155 6. html).
While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.The FY24 ATRP FRA mechanism is intended to support preclinical or animal research and may not be used for clinical research or clinical trials.
Applicants seeking funding for a clinical trial or clinical research should consider the FY24 ATRP Clinical Research Award mechanism (Funding Opportunity Number:
HT9425FY24ATRPCRA).A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 4 6. 102 (45 CFR 4 6. 102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research.
Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects.
Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or coinvestigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.
Research meeting this definition may include but is not limited to:
(a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under §4 6. 104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 ATRP FRA should not exceed $500,000 (Research Level 1) or $750,000 (Research Level 2).
Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 202 5. The CDMRP expects to allot approximately $ 2. 5M to fund approximately two FRA – Research Level 1 applications and two FRA – Research Level 2 applications.
Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government.
Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds.
It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 203 0.
Research addressing all types of arthritis is encouraged including but not limited to osteoarthritis, post-traumatic arthritis, inflammatory arthritis, juvenile arthritis, and rheumatoid arthritis.
The ATRP encourages applications that address sex as a biological variable and understudied arthritis types.
The ATRP also encourages applicants to consider whether large data sets or existing studies/consortia can be leveraged to maximize the potential impact of proposed studies.Applicants must address how the proposed research may eventually impact patient care and reduce the burden of disease.
It is expected that any research findings would benefit Service Members, their Families, Veterans, and the general public.
To meet the intent of the award mechanism, applications must specifically address at least one FY24 ATRP FRA focus area, listed in Section II.A.1, above.
Important aspects of this award mechanism include:Impact:
A key aspect of this award mechanism is impact.
The application should explicitly state how outcomes of the proposed research will have a significant impact on the advancement of arthritis research, potential for exploration of novel ideas, and/or patient care practices.
The application should clearly indicate how the research addresses the impact of arthritis in the military, which may include its effect on Service Member recruitment, retention, and recovery.
Applicants may also choose to include impacts to the Military Health System, which provides health care support to Service Members and their Families (Eligibility TRICARE).Research Levels:
The FY24 ATRP FRA offers funding for two Research Levels (refer to Section II.D.5 Funding Restrictions).
Only one Research Level category may be chosen per application.
It is the responsibility of the applicant to select the level that aligns with the scope of the proposed research.
The Research Level should be selected based on the research scope and not on the amount of the budget.
The following are generalized descriptions of the scope of the research appropriate for each level:• Research Level 1:
Supports exploratory, high-risk/high-reward research that is in the early stages of idea development.
Research must have the potential to yield new avenues of investigation, such as new approaches, new research tools, or new paradigms.
Early career investigators are particularly encouraged to apply to this research level.• Research Level 2:
Supports the advancement of preclinical research toward clinical translation.Preliminary data are required:
Applications must include preliminary and/or published data to support the proposed research project.
The included data may originate from other researchers or research conducted by the applicant(s).
Applicants must demonstrate logical reasoning for the proposed work.
To be competitive, the application must include a sound scientific rationale and a well-formulated, testable hypothesis established through a critical review and analysis of the literature.Advancing Women’s Health Research and Innovation:
The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable.
Such research should relate anticipated project findings to improvements in women’s health outcomes and/or advancing knowledge for women's health.
The ATRP therefore encourages research that addresses how arthritis and arthritis care may affect women uniquely, disproportionately, or differently from men.Rigor of Experimental Design:
All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research.
The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature1155 6. html).
While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.The FY24 ATRP FRA mechanism is intended to support preclinical or animal research and may not be used for clinical research or clinical trials.
Applicants seeking funding for a clinical trial or clinical research should consider the FY24 ATRP Clinical Research Award mechanism (Funding Opportunity Number:
HT9425FY24ATRPCRA).A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 4 6. 102 (45 CFR 4 6. 102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research.
Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects.
Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or coinvestigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.
Research meeting this definition may include but is not limited to:
(a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under §4 6. 104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 ATRP FRA should not exceed $500,000 (Research Level 1) or $750,000 (Research Level 2).
Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 202 5. The CDMRP expects to allot approximately $ 2. 5M to fund approximately two FRA – Research Level 1 applications and two FRA – Research Level 2 applications.
Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government.
Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds.
It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 203 0.
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
http://www.acf.hhs.gov/grants/open/foa/view/HHS-2011-ACF-OHS-CH-R05-0252
Additional Information of Eligibility:
Faith-based and community organizations that meet eligibility requirements are eligible to receive awards under this funding opportunity announcement.
Individuals, foreign entities, and sole proprietorship organizations are not eligible to compete for, or receive, awards made under this announcement.
Full Opportunity Web Address:
http://www.acf.hhs.gov/grants/open/foa/view/HHS-2011-ACF-OHS-CH-R05-0252
Contact:
Agency Email Description:
CDMRP Help Desk
Agency Email:
Date Posted:
2024-08-16
Application Due Date:
Archive Date:
2024-11-29
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